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This extension of gap bonds during in vitro maturation in the presence of PDE4 inhibitors could allow passage of metabolites, ions, nucleotides and amino acids, which improve oocyte cytoplasm maturation, bringing it near synchronization of nuclear and cytoplasmic maturation, which would favor blastocyst production and quality

Abstract Doxorubicin (DOX) is still one of the leading compounds for cancer chemotherapy, but its clinical application has been restricted by the drug resistance

Adverse events occurring in patients during the study period (113 patients)

Cells were grown to 100% confiuency before use